Heparin-associated skin necrosis.
نویسندگان
چکیده
A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon.
منابع مشابه
Low Molecular Weight Heparin-Induced Skin Necrosis: A Case Report
Low molecular weight heparins (LMWHs) are the standard agents used for antithrombotic therapy and prophylaxis. Despite their widespread use, reports about adverse effects from LMWHs are very scarce. Heparin-induced skin necrosis at the injection site is a rare adverse effect, more commonly associated with unfractionated heparin (UFH) rather than with LMWH, while its mechanism remains unclear. T...
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Massive skin and soft tissue necrosis is a rare but potentially fatal complication of warfarin therapy in 0-01 to 01 % of patients receiving the drug,1 but is not usually associated with heparin therapy unless limited to the site of subcutaneous injection.2 In warfarin therapy, the aetiology of this complication remains unknown but has been associated with the protein C /protein S system. Prote...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 66 777 شماره
صفحات -
تاریخ انتشار 1990